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Nicotinamide Adenine Dinucleotide. That’s the scientific name for NAD+, and chances are you’ve already encountered this ingredient (just maybe not in a skincare bottle).
NAD+ has very quickly become one of the most talked about ingredients in wellness circles, showing up in longevity supplements, injectables, IV drips, and biohacking routines long before it made its debut in topical formulas.
Now? That very same molecule is emerging as one of skincare’s most closely watched additions. This is what it is, and what it can do for our skin.
NAD+ is a coenzyme found naturally in every living cell, where it plays an essential role in cellular energy production and repair. Within the body, NAD+ fuels the mitochondria (the powerhouse of the cell) enabling all processes that keep skin cells functioning, repairing, and renewing themselves.
As skin inevitably ages NAD+ levels start to decline, and the cell’s capacity for efficient repair and renewal then slows. When/if applied topically, NAD+ aims to replenish what time will gradually deplete, going skin the resources it needs to support its own life cycle.
“The reason it may seem “new” is because NAD+ has been quite limited in topical skincare due to the fact that it is a fragile ingredient that cannot typically be stabilized for skincare formulations. What you’ll see frequently on the market is therefore NAD+ precursors, as these are easy to stabilize,” confirms Dr. Benjie Limketkai, Noble Panacea Chief Technology Officer. It is similar to the challenges of using pure L-Ascorbic Acid (Vitamin C), as this is such a tricky active to work with from a formulation perspective that many products on the market use Vitamin C derivatives instead. Thanks to our OSMV™ Technology we frequently get to “break the rules” of formulation challenges and this new product launch is so innovative because of just that! We are able to stabilize NAD+ and deliver it in a topical skincare formulation thanks to our groundbreaking encapsulation and delivery system.”
Because NAD+ operates at a cellular level, its effect on skin tends to show up as a general improvement in overall skin resilience and vitality, rather than targeted single concerns.
However! With consistent use, NAD+ has been associated with:
NAD+ will always perform best as part of a considered formulation, working alongside active ingredients that also prioritize cellular repair. Niacinamide is a direct precursor to NAD+, meaning these two ingredients will work in harmony to boost the body’s own production of the coenzyme. Peptides are another natural pairing for the role they play in structural renewal of skin. Then you have hydrating ingredients like hyaluronic acid which help maintain a stable environment for the most effective form of repair to take place.
Combining NAD+ with retinoids is a particularly powerful way to approach skin transformation. A retinol or retinal will accelerate cell turnover while NAD+ supports the underlying energy production that makes effective repair possible in the first place. Used together, the two can offer a more complete approach to renewal.
Noble Panacea is one of the first to market with a topical formula that incorporates NAD+ because it is a notoriously large and unstable ingredient that degrades rapidly when exposed to light, oxygen, or water.
Our patented OSMV™ Technology encapsulates and protects NAD+ for a safe and superior delivery into the skin. This fragile ingredient is cocooned in a microscopic shell of biodegradable carbohydrates and fatty acids that travel deep within the skin before releasing its contents in a controlled and gradual manner.
NAD+ is one example of the growing interest in skincare that addresses aging at its source, prioritizing skin longevity, and capitalizing on cellular energy and repair processes that will visibly transform skin.
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